M Gilles Phan

Lecturer Paris UniversityCiTCoM
Tel :: Number

Informations biographiques

Research :

  • Antibiotics resistance
  • Bacterial secretion systems
  • Structural biology (crystallography, SAXS and cryo-EM)
  • Proteins cloning, expression and purification
  • Membrane proteins
  • Macromolecules interaction

Activities :

  • Research Commission member of the Health Faculty
  • Responsible of L1 level for the undergraduate studies “Sciences for Health”
  • “Paris Rive Gauche” BAG coordinator (SOLEIL and ESRF)
  • Contact person for pharmaceutical students guidance

Publications :



11 documents

Articles dans une revue

  • Marie Glavier, Dhenesh Puvanendran, Dimitri Salvador, Marion Decossas, Gilles Phan, et al.. Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-18770-5⟩. ⟨hal-03006629⟩
  • Dimitri Salvador, Marie Glavier, Guy Schoehn, Gilles Phan, Jean-Christophe Taveau, et al.. Minimal nanodisc without exogenous lipids for stabilizing membrane proteins in detergent-free buffer. Biochimica et Biophysica Acta:Biomembranes, Elsevier, In press, 1861 (4), pp.852-860. ⟨10.1016/j.bbamem.2019.01.013⟩. ⟨hal-02070464⟩
  • Karim Housseini B Issa, Gilles Phan, Isabelle Broutin. Functional Mechanism of the Efflux Pumps Transcription Regulators From Pseudomonas aeruginosa Based on 3D Structures. Frontiers in Molecular Biosciences, Frontiers Media, 2018, 5, ⟨10.3389/fmolb.2018.00057⟩. ⟨hal-02150022⟩
  • Yvette Véronique Ntsogo Enguéné, Gilles Phan, Cyril Garnier, Arnaud Ducruix, Thierry Prangé, et al.. Xenon for tunnelling analysis of the efflux pump component OprN. PLoS ONE, Public Library of Science, 2017. ⟨hal-02150038⟩
  • Gilles Phan, Martin Picard, Isabelle Broutin. Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies. Antibiotics, MDPI, 2015, 4 (4), pp.544-566. ⟨10.3390/antibiotics4040544⟩. ⟨hal-02150041⟩
  • Laura Monlezun, Gilles Phan, Houssain Benabdelhak, Marie-Bernard Lascombe, Véronique Enguéné, et al.. New OprM structure highlighting the nature of the N-terminal anchor. Frontiers in Microbiology, Frontiers Media, 2015, 6, ⟨10.3389/fmicb.2015.00667⟩. ⟨hal-02150031⟩
  • Véronique Yvette Ntsogo Enguéné, Alice Verchère, Gilles Phan, Isabelle Broutin, Martin Picard. Catch me if you can: a biotinylated proteoliposome affinity assay for the investigation of assembly of the MexA-MexB-OprM efflux pump from Pseudomonas aeruginosa. Frontiers in Microbiology, Frontiers Media, 2015, 6, ⟨10.3389/fmicb.2015.00541⟩. ⟨hal-02150029⟩
  • Yann Ferrandez, Laura Monlezun, Gilles Phan, Houssain Benabdelhak, Philippe Bénas, et al.. Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis. Electrophoresis, Wiley-VCH Verlag, 2012, 33 (8), pp.1282-1287. ⟨10.1002/elps.201100541⟩. ⟨hal-02519724⟩
  • Gilles Phan, Houssain Benabdelhak, Marie-Bernard Lascombe, Philippe Bénas, Stéphane Réty, et al.. Structural and Dynamical Insights into the Opening Mechanism of P. aeruginosa OprM Channel. Structure, Elsevier (Cell Press), 2010, 18 (4), pp.507-517. ⟨10.1016/j.str.2010.01.018⟩. ⟨hal-02519908⟩
  • Lucie Vettoretti, Patrick Plésiat, Cédric Muller, Farid El'Garch, Gilles Phan, et al.. Efflux Unbalance in Cystic Fibrosis Isolates of Pseudomonas aeruginosa.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2009, epub ahead of print. ⟨10.1128/AAC.01024-08⟩. ⟨hal-00378746⟩

Thèses

  • Gilles Phan. Étude structurale du système d'efflux membranaire MexXY-OprM impliqué dans la résistance aux antibiotiques chez Pseudomonas aeruginosa. Biochimie [q-bio.BM]. Université René Descartes - Paris V, 2008. Français. ⟨tel-00512797⟩