Mme Liu Wang Qing

Senoir Lecturer Paris UniversityCitCoM
Tel :: Number

Informations biographiques

Research :

  • Peptide synthesis
  • Organic synthesis
  • Medicinal Chemistry
  • Biochemical tests


  • Duflocq, J. Zhou, F. Huguenot, M. Vidal, W.-Q. Liu*. One-pot oxime ligation from peptides bearing thiazolidine and aminooxyacetyl groups. RSC Adv., 2020, 10, 17681-5. (IF 3.119), DOI: 10.1039/d0ra03235b
  • Brachet, A. Dumond, W.-Q. Liu, M. Fabre, M. Selkti, F. Raynaud, O. Hermine, R. Benhida, P. Belmont, C. Garbay, Y. Lepelletier, C. Ronco, G. Pages, L. Demange. Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent. Bioorg. Med. Chem. Lett. 2019, 29, 126710-126715. (co-1er auteur). (IF 2.448), DOI: 10.1016/j.bmcl.2019.126710
  • Wang, P. Coric, S. Broussy, R. Di Stasi, L. Zhou, L. D. D’Andrea, L. Ji, M. Vidal, S. Bouaziz, W.-Q. Liu*. Structural studies of the binding of an antagonistic cyclic peptide to the VEGFR1 domain 2. Eur. J. Med. Chem. 2019, 169, 65-75. (IF 4.816), DOI: 10.1016/j.ejmech.2019.02.069
  • Wang, P. Coric, K. Zhu, W.-Q. Liu, M. Vidal, S. Bouaziz, S. Broussy. Synthesis and characterization of water-soluble macrocyclic peptides stabilizing protein α-turn. Org. Biomol. Chem. 2018, 16, 459-471. (IF 3.564), DOI: 10.1039/c7ob02852k
  • -Q. Liu, Y. Lepelletier, M. Montes, L. Borriello, R. Jarray, R. Grepin, B. Leforban, A. Loukaci, R. Benhida, O. Hermine, S. Dufour, G. Pages, C. Garbay, F. Raynaud, R. Hadj-Slimane, L. Demange. NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model. Cancer Lett. 2018, 414, 88-98. (IF 6.375), DOI: 10.1016/j.canlet.2017.10.039
  • Wang, L. Zhou, M. Reille-Seroussi, N. Gagey-Eilstein, S. Broussy, T. Zhang, L. Ji, M. Vidal, W.-Q. Liu*. Identification of peptidic antagonists of vascular endothelial growth factor receptor-1 by scanning the binding epitopes of its ligands. J. Med. Chem. 2017, 60, 6598-6606. (IF 6.259), DOI: 10.1021/acs.jmedchem.7b00283
  • Wang, W.-Q. Liu, N. Saraux, M. Vidal, S. Broussy. Solid Phase Synthesis of Constrained 13-Membered Peptide Macrocycles Employing Fukuyama-Mitsunobu Alkylations. Tetrahedron Lett. 2015, 56, 2456-2459. (IF 2.347), DOI: 10.1016/j.tetlet.2015.03.091
  • Wang, S. Broussy, N. Gagey-Eilstein, M. Reille-Seroussi, F. Huguenot, M. Vidal, W.-Q. Liu*. Inhibition of VEGF/VEGFR interaction by a series of C-terminal modified cyclic peptides. Receptors and Clinical Investigation 2015, 2(1), e534. (Invited highlight), DOI: 10.14800/rei.534
  • -Q. Liu, L. Borriello, B. Allain, S. Pavoni, O. Hermine, C. Garbay, F. Raynaud, Y. Lepelletier, L. Demange. New peptides structurally related to VEGF-A165 exon 7 and 8 encoded domains antagonize its binding to NRP-1 and VEGF-R1. Int. J. Pept. Res. Ther. 2015, 21, 117-124. (IF 0.905). DOI: 10.1007/s10989-014-9436-6
  • Wang, N. Gagey-Eilstein, S. Broussy, M. Reille-Seroussi, F. Huguenot, M. Vidal, W.-Q. Liu*. Design and Synthesis of C-Terminal Modified Cyclic Peptides as VEGFR1 Antagonists. Molecules 2014, 19, 15391-15407. (IF 2.416), DOI: 10.3390/molecules191015391
  • -Q. Liu, V. Megale, L. Borriello, B. Leforban, M. Montès, E. Goldwaser, N. Gresh, J. P. Piquemal, R. Hadj-Slimane, O. Hermine, C. Garbay, F. Raynaud, Y. Lepelletier, L. Demange. Synthesis and structure-activity relationship of non-peptidic antagonists of neuropilin-1 receptor. Bioorg. Med. Chem. Lett. 2014, 24, 4254-4259. (IF 2.420), DOI: 10.1016/j.bmcl.2014.07.028
  • Dourlat, W.-Q. Liu, F. Sancier, T. Edmonds, P. Pamonsinlapatham, F. Cruzalegui, and C. Garbay. A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity. Biochimie 2009, 91, 996-1002. (IF 3.897), DOI: 10.1016/j.biochi.2009.05.006
  • Dourlat, B. Valentin, W.-Q. Liu, and C. Garbay. New synthesis of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors. Bioorg. Med. Chem. Lett. 2007, 17, 3943-3946. (IF 2.604), DOI: 10.1016/j.bmcl.2007.04.107
  • Gril, M. Vidal, F.Assayag, M.-F. Poupon, W.-Q. Liu and C. Garbay. Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has anti-tumor effects in human cancer xenografts alone and in combination with docetaxel. Int. J. Cancer 2007, 121, 407-415. (IF 4.555), DOI: 10.1002/ijc.22674
  • Dourlat, W.-Q. Liu, N. Gresh and C. Garbay. Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines. Bioorg. Med. Chem. Lett. 2007, 17, 2527-2530. (IF 2.604), DOI: 10.1016/j.bmcl.2007.02.016
  • Leroux, N. Gresh, W.-Q. Liu, C. Garbay and B. Maigret. Role of water molecules for binding inhibitors in the SH2 domain of Grb2: A molecular dynamics study. J. Mol. Struct: THEOCHEM 2007, 806, 51-66. (IF 1.112), DOI: 10.1016/j.theochem.2006.11.010
  • Gril, W.-Q. Liu, C. Lenoir, C. Garbay and M. Vidal. Affinity chromatography for purification of the modular protein growth factor receptor-bound protein 2 and development of a screening test for growth factor receptor-bound protein 2 Src homology 3 domain inhibitor using peroxidase-linked ligand. Anal. Biochem. 2006, 351, 93-99. (IF 2.948), DOI: 10.1016/j.ab.2005.12.032
  • Vidal, W.-Q. Liu, C. Lenoir, J. Salzmann, N. Gresh and C. Garbay. Design of peptoid analog dimers and measure of their affinity for Grb2 SH3 domains. Biochemistry 2004, 43: 7336-7344. (IF 4.008), DOI: 10.1021/bi030252n
  • -Q. Liu, M. Vidal, C. Olszowy, E. Million, C. Lenoir, H. Dhôtel and C. Garbay. Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs. J. Med. Chem. 2004, 47, 1223-1233. (IF 5.076), DOI: 10.1021/jm031005k
  • -Q. Liu, C. Olszowy, L. Bischoff and C. Garbay. Enantioselective synthesis of (2S)-2-(4-phosphonophenylmethyl)-3-aminopropanoic acid suitably protected for peptide synthesis. Tetrahedron letters 2002, 43, 1417-1419. (IF 2.357), DOI: 10.1016/S0040-4039(02)00004-7
  • Nioche, W.-Q. Liu, I. Boutin, F. Charbonnier, M. T. Latreille, M. Vidal, B. P. Roques, C. Garbay, and A. Ducruix. Crystal structures of the SH2 domain of Grb2: Highlight on the binding of a new highly affine. J. Mol. Biol. 2002, 315, 1167-1177. (IF 5.359), DOI: 10.1006/jmbi.2001.5299
  • -Q. Liu, M. Vidal, C. Mathé, C. Perigaud, and C. Garbay. Inhibition of the Ras-dependent mitogenic by phosphopeptide prodrugs with antiproliferative properties. Bioorg. Med. Chem. Lett. 2000, 10, 669-672. (IF 1.927), DOI: 10.1016/s0960-894x(00)00077-9
  • -Q. Liu, M. Vidal, N. Gresh, B. P. Roques and C. Garbay. Small peptides containing phosphotyrosine and adjacent aMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain. J. Med. Chem. 1999, 42, 3737-3741. (IF 4.079), DOI: 10.1021/jm9911074
  • Cussac, M. Vidal, C. Leprince, W.-Q. Liu, F. Cornille, G. Tiraboschi, B. P. Roques and Christiane Garbay. A Sos-derived peptidimer blocks the ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity. FASEB J. 1999, 13, 31-38. (IF 11.880), DOI: 10.1096/fasebj.13.1.31
  • -Q. Liu, B. P. Roques and C. Garbay-Jaureguiberry. Enantioselective synthesis of L-2,3,5,6-tetrafluoro-4-(phosphonomethyl)phenylalanine, a novel non-hydrolyzable phosphotyrosine mimetic and L-4-(phosphonodifluoromethyl)phenylalanine. Tetrahedron Lett. 1997, 38, 1389-1392. (IF 2.500), DOI: 10.1016/S0040-4039(97)00027-0
  • -Q. Liu, F. Carreaux, H. Meudal, B. P. Roques and C. Garbay-Jaureguiberry. Synthesis of constrained 4-(phosphonomethyl)phenylalanine derivatives as hydrolytically stable analogs of O-phosphotyrosine. Tetrahedron 1996, 52, 4411-4422. (IF 2.232), DOI: 10.1016/0040-4020(96)00085-3
  • Baczko, W.-Q. Liu, B. P. Roques and C. Garbay-Jaureguiberry. New synthesis of D,L-Fmoc protected 4-phosphonomethylphenylalanine derivatives and their enzymatic resolution. Tetrahedron 1996, 52, 2021-2030. (IF 2.497), DOI: 10.1016/0040-4020(95)01003-3
  • -Q. Liu, B. P. Roques and C. Garbay-Jaureguiberry. Enantioselective synthesis of N-Fmoc protected di-tert-butyl 4-phosphonomethyl-L-phenylalanine: a hydrolytically stable analogue of O-phosphotyrosine. Tetrahedron: Asymmetry 1995, 6, 647-650. (IF 2.226), DOI: 10.1016/0957-4166(95)00050-Y