M Nicolas Leulliot

Professor – Team leader – Director of the CiTCoM Laboratory Paris UniversityCiTCoM
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Informations biographiques

Research :

  • Protein/RNA structural biology: Cristallography, Cryo-EM, SAXS, Biophysical methods
  • Function of Protein-Protein and Protein-RNA complexes in health and desease
  • Proteins involved in ribosome biogenesis pathway and their link to cancer
  • Structure-function-activity of chemical inhibitors
  • Molecular modelling


  1. Hamzaoui, N et al.(2020)Genetic, structural, and functional characterization of POLE polymerase proofreading variants allows cancer risk prediction. Genet Med 22 (9):1533-1541.
  2. Joret, C et al.(2018)The Npa1p complex chaperones the assembly of the earliest eukaryotic large ribosomal subunit precursor. PLoS Genet 14 (8):e1007597.
  3. Madru, C, Leulliot, N, Lebaron, S[Ribosomes synthesis at the heart of cell proliferation]. Med Sci (Paris) 33 (6-7):613-619.
  4. Deschamps, P, Réty, S, Bareille, J, Leulliot, N(2017)Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates. Acta Crystallogr F Struct Biol Commun 73 (Pt 6):336-341.
  5. Juge, PA et al.(2017)Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. Eur Respir J 49 (5):.
  6. Robert-Paganin, J et al.(2017)Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding. Nucleic Acids Res 45 (3):1539-1552.
  7. Tlemsani, C et al.(2016)SETD2 and DNMT3A screen in the Sotos-like syndrome French cohort. J Med Genet 53 (11):743-751.
  8. Mitterer, V et al.(2016)Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation. Nat Commun 7 :10336.
  9. Greber, BJ et al.(2016)Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation. Cell 164 (1-2):91-102.
  10. Rety, S, Deschamps, P, Leulliot, N(2015)Structure of Escherichia coli tryptophanase purified from an alkaline-stressed bacterial culture. Acta Crystallogr F Struct Biol Commun 71 (Pt 11):1378-83.
  11. Madru, C et al.(2015)Chaperoning 5S RNA assembly. Genes Dev 29 (13):1432-46.
  12. Loc'h, J et al.(2014)RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis. PLoS Biol 12 (5):e1001860.
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