Mme Sylvie Nonin-Lecomte

Researcher – PI CNRSCiTCoM
Tel :: Number

Informations

Research :

  • RNA-protein and RNA-RNA interactions
  • Nucleic acid structure and dynamics
  • Protein translation and trans-translation in bacteria
  • Structural studies of new targets for anti-infectives
  • NMR spectroscopy and molecular modeling



34 documents

Articles dans une revue

  • Sylvie Nonin-Lecomte, Laurence Fermon, Brice Felden, Marie-Laure Pinel-Marie. Correction: Nonin-Lecomte et al. Bacterial Type I Toxins: Folding and Membrane Interactions. Toxins 2021, 13, 490. Toxins, 2021, 13 (12), pp.878. ⟨10.3390/toxins13120878⟩. ⟨hal-03660711⟩
  • Xiao Wang, Xiaowei Chen, Serge Bouaziz, Sylvie Nonin-Lecomte. Acetonitrile allows indirect replacement of non‐deuterated lipid detergents by deuterated lipid detergents for the NMR study of detergent‐soluble proteins. Protein Science, 2021, ⟨10.1002/pro.4174⟩. ⟨hal-03331437⟩
  • Sylvie Nonin-Lecomte, Laurence Fermon, Brice Felden, Marie-Laure Pinel-Marie. Bacterial Type I Toxins: Folding and Membrane Interactions. Toxins, 2021, 13 (7), pp.490. ⟨10.3390/toxins13070490⟩. ⟨hal-03286997v2⟩
  • Rafael Schneider, Muriel Primon-Barros, Rafael Gomes von Borowski, Sophie Chat, Sylvie Nonin-Lecomte, et al.. Pseudonajide peptide derived from snake venom alters cell envelope integrity interfering on biofilm formation in Staphylococcus epidermidis. BMC Microbiology, 2020, 20 (1), pp.237. ⟨10.1186/s12866-020-01921-5⟩. ⟨hal-02928038⟩
  • Charlotte Guyomar, Marion Thepaut, Sylvie Nonin-Lecomte, Agnes Mereau, Renan Goude, et al.. Reassembling green fluorescent protein for in vitro evaluation of trans-translation. Nucleic Acids Research, 2020, 48 (4), pp.e22-e22. ⟨10.1093/nar/gkz1204⟩. ⟨hal-02440937⟩
  • Xiaowei Chen, Pascale Coric, Valéry Larue, Serge Turcaud, Xiao Wang, et al.. The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag. European Journal of Medicinal Chemistry, 2020, 204, pp.112634. ⟨10.1016/j.ejmech.2020.112634⟩. ⟨hal-02914317⟩
  • Ehsan Ranaei-Siadat, Cécile Mérigoux, Bili Seijo, Luc Ponchon, Jean-Michel Saliou, et al.. In vivo tmRNA protection by SmpB and pre-ribosome binding conformation in solution. RNA, 2014, 20 (10), pp.1607-1620. ⟨10.1261/rna.045674.114⟩. ⟨hal-02344587⟩
  • Ehsan Ranaei-Siadat, Céline Fabret, Bili Seijo, Frédéric Dardel, Henri Grosjean, et al.. RNA-methyltransferase TrmA is a dual-specific enzyme responsible for C 5 - methylation of uridine in both tmRNA and tRNA. RNA Biology, 2014, 10 (4), pp.572-578. ⟨10.4161/rna.24327⟩. ⟨hal-02344603⟩
  • Luc Ponchon, Marjorie Catala, Bili Seijo, Marguerite El Khouri, Frédéric Dardel, et al.. Co-expression of RNA–protein complexes in Escherichia coli and applications to RNA biology. Nucleic Acids Research, 2013, 41 (15), pp.e150-(1-13). ⟨10.1093/nar/gkt576⟩. ⟨hal-02344594⟩
  • Nour Sayed, Sylvie Nonin-Lecomte, Stéphane Réty, Brice Felden. Functional and Structural Insights of a Staphylococcus aureus Apoptotic-like Membrane Peptide from a Toxin-Antitoxin Module. Journal of Biological Chemistry, 2012, 287 (52), pp.43454-43463. ⟨10.1074/jbc.M112.402693⟩. ⟨hal-02344624⟩
  • Nour Sayed, Sylvie Nonin-Lecomte, Stephane Rety, Brice Felden. Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module.. Journal of Biological Chemistry, 2012, 287 (52), pp.43454-63. ⟨10.1074/jbc.M112.402693⟩. ⟨inserm-00762197⟩
  • Julien Robert-Paganin, Sylvie Nonin-Lecomte, Stéphane Réty. Crystal Structure of an EAL Domain in Complex with Reaction Product 5′-pGpG. PLoS ONE, 2012, 7 (12), pp.e52424. ⟨10.1371/journal.pone.0052424⟩. ⟨hal-02344629⟩
  • Julien Robert-Paganin, Sylvie Nonin-Lecomte, Stéphane Réty. Crystal Structure of an EAL Domain in Complex with Reaction Product 5′-pGpG. PLoS ONE, 2012, 7 (12), pp.e52424. ⟨10.1371/journal.pone.0052424⟩. ⟨hal-02966930⟩
  • Luc Ponchon, Geneviève Beauvais, Sylvie Nonin-Lecomte, Frédéric Dardel. A generic protocol for the expression and purification of recombinant RNA in Escherichia coli using a tRNA scaffold. Nature Protocols, 2009, 4 (6), pp.947-959. ⟨10.1038/nprot.2009.67⟩. ⟨hal-02344647⟩
  • Sylvie Nonin-Lecomte, Noella Germain-Amiot, Reynald Gillet, Marc Hallier, Luc Ponchon, et al.. Ribosome hijacking: a role for small protein B during trans-translation.. EMBO Reports, 2009, 10 (2), pp.160-5. ⟨10.1038/embor.2008.243⟩. ⟨inserm-00706654⟩
  • Sylvie Nonin-Lecomte, Noëlla Germain-Amiot, Reynald Gillet, Marc Hallier, Luc Ponchon, et al.. Ribosome hijacking: a role for small protein B during trans-translation. EMBO Reports, 2009, 10 (2), pp.160-165. ⟨10.1038/embor.2008.243⟩. ⟨hal-02344654⟩
  • S. Nonin-Lecomte, Brice Felden, Frédéric Dardel. NMR structure of the Aquifex aeolicus tmRNA pseudoknot PK1: new insights into the recoding event of the ribosomal trans-translation. Nucleic Acids Research, 2006, 34 (6), pp.1847-1853. ⟨10.1093/nar/gkl111⟩. ⟨hal-02344673⟩
  • Sylvie Nonin-Lecomte, Brice Felden, Frédéric Dardel. NMR structure of the A. aeolicus tmRNA pseudoknot PK1: new insights into the recoding event of the ribosomal trans-translation.. Nucleic Acids Research, 2006, 34, pp.1847-1853. ⟨10.1093/nar/gkl111⟩. ⟨hal-00021774⟩
  • Sylvie Nonin-Lecomte, Frédéric Dardel, Patrick Lestienne. Self-organisation of an oligodeoxynucleotide containing the G- and C-rich stretches of the direct repeats of the human mitochondrial DNA.. Biochimie, 2005, 87 (8), pp.725-35. ⟨10.1016/j.biochi.2005.03.009⟩. ⟨hal-00219761⟩
  • Sylvie Nonin-Lecomte, F. Dardel, P Lestienne. Self-organisation of an oligodeoxynucleotide containing the G- and C-rich stretches of the direct repeats of the human mitochondrial DNA. Biochimie, 2005, 87 (8), pp.725-735. ⟨10.1016/j.biochi.2005.03.009⟩. ⟨hal-02344712⟩
  • Cyril Gaudin, Sylvie Nonin-Lecomte, Carine Tisné, Sophie Corvaisier, Valérie Bordeau, et al.. The tRNA-like domains of E coli and A.aeolicus transfer-messenger RNA: structural and functional studies.. Journal of Molecular Biology, 2003, 331 (2), pp.457-71. ⟨10.1016/S0022-2836(03)00760-5⟩. ⟨hal-00219759⟩
  • K Snoussi, S. Nonin-Lecomte, J.-L Leroy. The RNA i-motif. Journal of Molecular Biology, 2001, 309 (1), pp.139-153. ⟨10.1006/jmbi.2001.4618⟩. ⟨hal-02344733⟩
  • Sylvie Nonin-Lecomte, Jean Louis Leroy. Structure of a C-rich strand fragment of the human centromeric satellite III: a pH-dependent intercalation topology. Journal of Molecular Biology, 2001, 309 (2), pp.491-506. ⟨10.1006/jmbi.2001.4679⟩. ⟨hal-02344730⟩
  • Sylvie Nonin-Lecomte, Chin H Lin, Dinshaw J Patel. Additional Hydrogen Bonds and Base-Pair Kinetics in the Symmetrical AMP-DNA Aptamer Complex. Biophysical Journal, 2001, 81 (6), pp.3422-3431. ⟨10.1016/S0006-3495(01)75974-7⟩. ⟨hal-02344725⟩
  • Sylvie Nonin, Anh Tuan Phan, Jean-Louis Leroy. Solution structure and base pair opening kinetics of the i-motif dimer of d(5mCCTTTACC): a noncanonical structure with possible roles in chromosome stability. Structure, 1997, 5 (9), pp.1231-1247. ⟨10.1016/S0969-2126(97)00273-6⟩. ⟨hal-02344745⟩
  • Sylvie Nonin, Feng Jiang, Dinshaw Patel. Imino proton exchange and base-pair kinetics in the AMP-RNA aptamer complex. Journal of Molecular Biology, 1997, 268 (2), pp.359-374. ⟨10.1006/jmbi.1997.0986⟩. ⟨hal-02344759⟩
  • Dinshaw J Patel, Asif K Suri, Feng Jiang, Licong Jiang, Pei Fan, et al.. Structure, recognition and adaptive binding in RNA aptamer complexes. Journal of Molecular Biology, 1997, 272 (5), pp.645-664. ⟨10.1006/jmbi.1997.1281⟩. ⟨hal-02344751⟩
  • Sylvie Nonin, J.-L. Leroy, M. Gueron. Acid-Induced Exchange of the Imino Proton in G.C Pairs. Nucleic Acids Research, 1996, 24 (4), pp.586-595. ⟨10.1093/nar/24.4.586⟩. ⟨hal-02344768⟩
  • Sylvie Nonin, Jean-Louis Leroy. Structure and Conversion Kinetics of a Bi-stable DNA i-motif: Broken Symmetry in the [d(5mCCTCC)]4 Tetramer. Journal of Molecular Biology, 1996, 261 (3), pp.399-414. ⟨10.1006/jmbi.1996.0472⟩. ⟨hal-02344764⟩
  • Sylvie Nonin, Jean-Louis Leroy, Maurice Guéron. Terminal Base Pairs of Oligodeoxynucleotides: Imino Proton Exchange and Fraying. Biochemistry, 1995, 34 (33), pp.10652-10659. ⟨10.1021/bi00033a041⟩. ⟨hal-02344774⟩

Chapitres d'ouvrage

  • Luc Ponchon, Geneviève Beauvais, Sylvie Nonin-Lecomte, Frédéric Dardel. Selective RNase H Cleavage of Target RNAs from a tRNA Scaffold. Methods in Molecular Biology series (Humana Press, series editor John M. Walker), pp.9-18, 2013, ⟨10.1007/978-1-62703-113-4_2⟩. ⟨hal-02344641⟩
  • Sylvie Nonin, Jl Leroy. Human centromeric satellite III cytosine-rich repeats (CCATT)n fold into the i-motif in vitro ; Solution structure of the d(mCCATTCCAUTCCUTTCC) monomer. Journal of Biomolecular Structure and Dynamics, 1999. ⟨hal-02344823⟩
  • Jl Leroy, Sylvie Nonin, Ann Tuan Phan, Maurice Guéron. Switching and Looping in i-motif Structures. Structure and Motion and Expression of biological macromolecules Sarma,R.H. and Sarma,M.H. (eds) Adenine Press, Schenectady, NY, 1998. ⟨hal-02344828⟩

Pré-publications, Documents de travail

  • Rafael Gomes von Borowski, Sophie Chat, Rafael Schneider, Sylvie Nonin-Lecomte, Serge Bouaziz, et al.. First-in-class matrix anti-assembly peptide prevents staphylococcal biofilm in vitro and in vivo. 2021. ⟨hal-03383344⟩