Mme Zaineb Kammoun

Lecturer Paris UniversityCiTCoM
Tel :: Number

Informations biographiques

Research :

- Structural and functional studies of macromolecular assembly
- Studies of factors involved in ribosome biogenesis

Selected Publications

- Dorin-Semblat D, Tétard M, Claës A, Semblat JP, Dechavanne S, Fourati Z, Hamelin R, Armand F, Matesic G, Nunes-Silva S, Srivastava A, Gangnard S, Lopez-Rubio JJ, Moniatte M, Doerig C, Scherf A, Gamain B. (2019). Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA. PLoS Biol. 10;17(6):e3000308.

- Fourati Z, Howard RJ, Heusser SA, Sauguet L, Hu H, Ruza RR, Lindahl E and Delarue M. (2018). Bimodal anesthetic modulation revealed by structure-function studies in a pentameric ligand-gated ion channel. Cell Rep. 23(4):993-1004. Cover article

- Hu H, Nemecz Á, Van Renterghem C, Fourati Z, Sauguet L, Corringer PJ, Delarue M. (2018). Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation. Proc Natl Acad Sci U S A. 115(17):E3959-E3968.

- Nemecz, Á., Hu, H., Fourati, Z., Van Renterghem, C., Delarue, M., and Corringer, P.-J. (2017). Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel. PLoS Biol. 15, e2004470.

- Charenton C, Gaudon-Plesse C, Fourati Z, Taverniti V, Back R, Kolesnikova O, Séraphin B, Graille M. (2017). A unique surface on the yeast Pat1 C-terminal domain directly recruits Dcp2 or Xrn1 to mRNAs for decapping and 5’-3’ mRNA degradation. Proc Natl Acad Sci U S A. 114(45): E9493-E9501.

- Fourati Z, Ruza RR, Laverty D, Drège E, Delarue-Cochin S, Joseph D, Koehl P, Smart T and Delarue M. (2016). Barbiturates bind in the GLIC ion channel pore and cause inhibition by stabilizing a closed state. J. Biol. Chem. doi:10.1074. Selected article of the week

- Sauguet L, Fourati Z, Prangé T, Delarue M and Colloc’h N. (2016). Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel. Plos One. Pone.0149795.

- Fourati, Z., Sauguet, L., and Delarue M. (2015). Genuine open form of the pentameric ligand-gated ion channel GLIC. Acta D cryst.71(Pt 3):454-60. Cover article

- Fourati, Z., Roy, B., Millan, C., Coureux, P.-D., Kervestin, S., van Tilbeurgh, H., He, F., Usón, I., Jacobson, A., and Graille, M. (2014). A Highly Conserved Region Essential for NMD in the Upf2 N-Terminal Domain. J. Mol. Biol. 426, 3689–3702.

- Fourati, Z., Kolesnikova, O., Back, R., Keller, J., Charenton, C., Taverniti, V., Plesse, C.G., Lazar, N., Durand, D., van Tilbeurgh, H., et al. (2014). The C-terminal domain from S. cerevisiae Pat1 displays two conserved regions involved in decapping factor recruitment. PloS One 9, e96828.