M Frédéric Dardel

Professor University Paris Cité

Biographical Info

Research Interests:

  • RNA-protein and RNA-RNA interactions
  • Protein translation in bacteria
  • Initiation of HIV-1 reverse transcription
  • Structural studies of new targets for anti-infectives
  • NMR spectroscopy of RNA and proteins
  • NMR screening
  • Bioinformatics

Selected Publications

1 – Chung F, Tisne C, Lecourt T, Dardel F, Micouin L (2007) NMR-guided fragment-based approach for the design of tRNALys3 ligands. Angew Chem Int Ed Engl 46: 4489-4491

2 – Ponchon L, Dardel F (2007) Recombinant RNA technology: the tRNA scaffold. Nature Methods 4: 571-576

3 – Barraud P, Golinelli-Pimpaneau B, Atmanene C, Sanglier S, Vand Dorsselaer A, Droogmans L, Dardel F, Tisné C (2008) Crystal structure of Thermus thermophilus tRNA m1A58 methyltransferase and biophysical characterization of its interaction with tRNA. J Mol Biol 377: 535-550.

4 – Lombes T, Bégis G, Maurice F, Turcaud S, Lecourt T, Dardel F, Micouin L (2008) NMR-Guided Fragment-Based Approach For the Design of AAC(6?)-Ib ligands. ChemBioChem 9: 1368-1371

5 – Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F (2008) Enzyme structural plasticity and emergence of broad spectrum antibiotic resistance. EMBO Rep 9: 344-349