Mme Magali Blaud » Team : Molecular RNA machineries and human pathologies

Mme Magali Blaud

Lecturer University Paris CitéCiTCoM
Tel :: Number

Biographical Info

Research :

  • Production and purification of recombinant proteins in the prokaryotic system
  • Extraction, purification and analysis of nucleic acids
  • Characterization of interactions between biomolecules (proteins / nucleic acids)
  • Functional studies of enzymatic activities
  • Biophysical characterization: spectrometry, fluorescence and circular dichroism
  • Structural study: crystallography, cryo-ME and SAXS

Activities:

  • Deputy director of the teaching department “Chemistry and physico-chemistry of drugs”
  • Head of the “Structural Biology” educational unit
  • Head of the “Research Biology” specialization of the POP I&R of the Faculty of Pharmacy
  • Responsible for supervising internships for the Pharmasciences course
  • Elected member of the management board of the Faculty of Pharmacy
  • Ambassador in education at the FEBS “Federation of European Biochemical Soieties”
  • Member elected to the board of directors and head of the GTE “Working Group on Education” of the SFBBM “French Society of Biochemistry and Molecular Biology”
  • Responsible for the SAXS BAG for the SOLEIL synchrotron (proposal 2017 then 2019)NMR spectroscopy of…

Publications :

  1. Kellermann, G, Leulliot, N, Cherfils-Vicini, J, Blaud, M, Brest, P(2024)Activated B-Cells enhance epitope spreading to support successful cancer immunotherapy. Front Immunol 15 :1382236.
  2. Ajjaji, D et al.(2022)Hepatitis C virus core protein uses triacylglycerols to fold onto the endoplasmic reticulum membrane. Traffic 23 (1):63-80.
  3. Vayssières, M, Bourgeois, G, Chardon, F, Tillault, AS, Blaud, M(2021)Detection and Labeling of Small Non-Coding RNAs by Splinted Ligation. Methods Mol Biol 2300 :65-72.
  4. Blaud, A, Maïder, A, Clark, IM(2021)Quantification of Ammonia Oxidizing Bacterial Abundances in Environmental Samples by Quantitative-PCR. Methods Mol Biol 2232 :135-146.
  5. Duval, R et al.(2020)A Photoalkylative Fluorogenic Probe of Guttiferone A for Live Cell Imaging and Proteome Labeling in Plasmodium falciparum. Molecules 25 (21):.
  6. Clark, IM et al.(2020)Edaphic factors and plants influence denitrification in soils from a long-term arable experiment. Sci Rep 10 (1):16053.
  7. Sissoko, A et al.(2020)A Chemically Stable Fluorescent Mimic of Dihydroartemisinin, Artemether, and Arteether with Conserved Bioactivity and Specificity Shows High Pharmacological Relevance to the Antimalarial Drugs. ACS Infect Dis 6 (7):1532-1547.
  8. Fu, Q et al.(2020)Effects of urease and nitrification inhibitors on soil N, nitrifier abundance and activity in a sandy loam soil. Biol Fertil Soils 56 (2):185-194.
  9. Colucci-Guyon, E et al.(2019)Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe. Chem Sci 10 (12):3654-3670.
  10. Malik, AA et al.(2018)Land use driven change in soil pH affects microbial carbon cycling processes. Nat Commun 9 (1):3591.
  11. Robert-Paganin, J et al.(2017)Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding. Nucleic Acids Res 45 (3):1539-1552.
  12. Bandje, K et al.(2016)Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum. Malar J 15 :248.
  13. Choudhary, S, Blaud, A, Osborn, AM, Press, MC, Phoenix, GK(2016)Nitrogen accumulation and partitioning in a High Arctic tundra ecosystem from extreme atmospheric N deposition events. Sci Total Environ 554-555 :303-10.
  14. Mitterer, V et al.(2016)Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation. Nat Commun 7 :10336.
  15. Blaud, A, Lerch, TZ, Phoenix, GK, Osborn, AM(2015)Arctic soil microbial diversity in a changing world. Res Microbiol 166 (10):796-813.
  16. Madru, C et al.(2015)Chaperoning 5S RNA assembly. Genes Dev 29 (13):1432-46.
  17. Tillault, AS et al.(2015)RNA size is a critical factor for U-containing substrate selectivity and permanent pseudouridylated product release during the RNA:Ψ-synthase reaction catalyzed by box H/ACA sRNP enzyme at high temperature. Biochimie 113 :134-42.
  18. Bourgeois, G, Chardon, F, Tillault, AS, Blaud, M(2015)Detection and labeling of small non-coding RNAs by splinted ligation. Methods Mol Biol 1296 :65-72.
  19. Loc'h, J et al.(2014)RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis. PLoS Biol 12 (5):e1001860.
  20. Rothé, B et al.(2014)Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly. Nucleic Acids Res 42 (3):2015-36.
  21. Fourmann, JB et al.(2013)Comparative study of two box H/ACA ribonucleoprotein pseudouridine-synthases: relation between conformational dynamics of the guide RNA, enzyme assembly and activity. PLoS One 8 (7):e70313.
  22. Walbott, H et al.(2011)The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. Genes Dev 25 (22):2398-408.
  23. Maenner, S et al.(2010)2-D structure of the A region of Xist RNA and its implication for PRC2 association. PLoS Biol 8 (1):e1000276.
  24. Alazard, R et al.(2005)Identification of the 'NORE' (N-Oct-3 responsive element), a novel structural motif and composite element. Nucleic Acids Res 33 (5):1513-23.
  25. Blaud, M et al.(2004)Characteristic patterns of N Oct-3 binding to a set of neuronal promoters. J Mol Biol 339 (5):1049-58.
  26. Blaud,(1846)On Chlorosis in Adults. West J Med Surg 6 (3):259-260.
  27. Blaud, M(1819)Observations and Cases Illustrating the Efficacy of Compressing the Carotid Arteries in Sanguineous Turgescence of the Cerebral Vessels. Med Chir J 1 (4):498-503.
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