M Arnaud Ducruix

Emeritus Professeur University Paris CitéCiTCoM
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Biographical Info

- Research :

  • Structural biology of membrane proteins
  • Bacterial efflux pumps
  • Crystallogenesis

- Administration de l’Enseignement et de la Recherche:

  • Vice-president of Paris Descartes University
  • Director of the department of “Physical-chemistry of drugs” at the Faculty of Pharmacy
  • Deputy Director of the Institute ” Médicament-Toxicologie-Chimie-Environnement” (IMTCE) of Paris Descartes University

- Last publications

  • Y. Ferrandez, L. Monlezun, G. Phan, H. Benabdelhak, P. Benas, N. Ulryck, P. Falson, A. Ducruix, M. Picard and I. Broutin (2012), Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis, Electrophoresis 2012, 33, 1282–1287
  • S. Trépout, J.C. Taveau, H. Benabdelhak, T. Granier, A. Ducruix, A. S. Frangakis, O. Lambert (2010), Structure of reconstituted bacterial membrane efflux pump by cryo-electron tomography, Biochim. Biophys. Acta 1798 (10) 1953-1960
  • G. Phan, H. Benabdelhak, M.B. Lascombe, P. Benas, S. Rety, M. Picard, A. Ducruix, C. Etchebest and I. Broutin (2010), Structural and Dynamical Insights into the Opening Mechanism of P. aeruginosa OprM Channel, STRUCTURE 18, 4, 507-517
  • I. Broutin, J.B. Jomain, E. Tallet, J. van Agthoven, B. Raynal, S. Hoos, B. B. Kragelund, P. A. Kelly, A. Ducruix, P. England, & V. Goffin (2010), Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2, Journal of Biological Chemistry, 285, 11, 8422-8433
  • Vettoretti L, Plésiat P, Muller C, El Garch F, Phan G, Attrée I, Ducruix A, Llanes C. (2009), Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients, Antimicrob Agents Chemother. May;53(5):1987-97.
  • Reffay M., Yann Gambin, Benabdelhak H., Phan G., Taulier N., Ducruix A., Hodges R.S., Urbach W. (2009), Tracking membrane protein association in model membranes, PLoS ONE. 2009;4(4):e5035. Epub 2009 Apr 1.
  • H. Dohi, R. Périon, M. Durka, M. Bosco, Y. Roué, F. Moreau, S. Grizot, A. Ducruix, S. Escaich, S. P. Vincent, Stereoselective glycal fluorophosphorylation: Synthesis of ADP-2-fluoro-heptose, an inhibitor of the LPS Biosynthesis, Chemistry (2008);14(31) 9530-9539.

- Books :

  • A. DUCRUIX AND R. GIEGÉ Methods of crystallization Crystallization of nucleic acids and proteins: A practical approach (A. Ducruix & R. Giegé Ed.), 1999, Oxford University Press.
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