The interests of our group lie in understanding the structural basis of molecular complexes and their link to human disease. The group is specialised in the structural determination of a wide range of molecules, from small molecular weight compounds (drugs, inhibitors, bioimetics,…)
Although it has been overlooked for a long time, translation, and more precisely the initiation step is the target of many regulatory mechanisms. In particular, it enables the cell to store mRNA in a repressed state that can be swiftly mobilised to react to stimuli. Among a galore of recently discovered examples we could cite the cases of maternal mRNA in oocytes, of the interferon mediated response to viral infection, or of post synaptic events in neurones.
The PNAS team is devoted to natural products under various aspects: isolation, analysis, synthesis. This team gathers a profound expertise in natural products, from extraction knowledge, to structural determination, advanced analysis of extracts, semi-synthesis, medicinal chemistry along with organic/organometallic methodology development and total synthesis
L’équipe « Chimie-Toxicologie Analytique et Cellulaire » s’est bâtie par agrégations successives de personnalités porteuses de savoir-faire spécifiques, au meilleur niveau dans leur domaine respectif, dans le but de permettre l’émergence de travaux originaux aux interfaces des différentes disciplines représentées.
Our team, specialized in the structural study of membrane proteins, focuses its research on the public health problem of antibiotic resistance responsible for the dramatic increase of multi-resistant bacteria all over the word.
Among the different ways used by bacteria to resist to antibiotics, the active efflux through tripartite efflux pumps is one of the most important.
Our team is involved in the determination of the three-dimensional structures of biological macromolecules of interest, as proteins and nucleic acids, by Nuclear Magnetic Resonance (NMR) and Molecular Modeling (MM). Our goal is to study the structure of their complexes to determine their mechanism of action and rationally design molecules capable of disrupting their interface and inhibit their activity.
Our project focuses on medicinal chemistry and translational research in order to validate new therapeutic targets, to design novel modulators (hits/leads), and to study responses of targeted therapies in clinics thanks to strong collaborations and to our hospital practitioners within the biology platform of the Cochin hospital.